Informative Research Papers - 998 Words

Clinical Question: In veterans with post-traumatic stress disorder (PTSD), does quetiapine monotherapy compared to placebo improve symptoms with tolerable adverse reactions? Search Strategy: A PubMed search was conducted to locate primary literature on the use of quetiapine as monotherapy in veterans with PTSD. Search terms used were â€Å"quetiapine†, â€Å"monotherapy† and â€Å"PTSD† to ensure appropriate studies were retrieved by the search. Rationale for Selection of Literature: The literature selected must addresses the use of quetiapine as monotherapy for PTSD. Thus, studies of quetiapine as adjunctive therapy were ruled out as they were irrelevant to the clinical question. After reviewing the available data from the literature search, the†¦show more content†¦There was a 1 week single-blind lead-in with placebo where non-responders (n= 80) were randomized in 1:1 ratio to quetiapine or placebo treatment for 12 weeks (1). Initially, patients started at a dose of 25mg at bedtime and clinical response and tolerability were used to guide titration (1). At the end, the dose ranged from 50 to 800mg daily with an average of 258mg daily for the quetiapine arm (1). Other psychotropic medications may not be used during the study except rescue mediations during the first 2 weeks including chloral hydrae for insomnia or agitation and lorazepam for anxiety or agitation (1). Participants were followed up during week 1, 2, 4, 8 and 12 for evaluation (1). The pri mary outcome was the total Clinician-Administered PTSD Scale (CAPS) score which the quetiapine arm had a greater reduction of score (75.40 to 53.85) than placebo arm (70.60 to 65.66) after 12 weeks with p=0.02 (1). For secondary outcomes, quetiapine arm also had higher reduction in CAPS re-experiencing score, CAPS hyperarousal score, Davidson Trauma Scale and Hamilton Depression Rating Scale (HAM-D) scores than the placebo arm at the end (1). However, there was no difference in CAPS avoidance/numbing score and negative symptom subscale of the Positive and Negative Syndrome Scale (1). For safety, the common side-effects in the quetiapine group were dry mouth (15.8%), somnolence (13.4%)Show MoreRelatedInformative Speech Essay855 Words   |  4 PagesWell chapter 13 contents the creative process for informative speaking. What informative speaking is how to choose a focused informative topic, how to conduct a research and informative outline? The chapter also contains how to organize t he body, introduction, and conclusion of the informative speech. Lastly chapter 13 contents explain how to prepare to present the speech and evaluate and informative speech. In order to make a well informative speech the speaker needs to be logical and purposefulRead MoreSample Resume : Lesson Construction Template1111 Words   |  5 Pages3357_640.jpg Today s lesson objective is: Students will write informative and explanatory texts to examine a topic and convey ideas, concepts, and information through the selection, organization, and analysis of relevant content. Sometimes you will be given the task to research and write about a topic. Maybe you already have been asked to do this. Open your digital notebook and write down some strategies you might use to research and organize information about a topic in order to put it all inRead MoreWhat Is The Importance Of The Title896 Words   |  4 Pagescore contents of the paper. It will be read by thousands, where few will read the whole paper. An improperly titled paper will get lost and will never be read because if the title of the paper is improper the reader will think the information is as well. 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